Exercise Pill Could Boost Fitness Without Exercising

exercise pillThe Exercise Pill Review. The EA study conducted on mice suggests it may be possible to develop a pill that will provide the same benefits as exercise. If an “exercise pill” does become available in the future it could be a lifesaver for anyone who has serious physical disabilities that prevent them from exercising.

A pill like that would also be very attractive to couch potatoes, people who spend their days stuck behind a desk, and long distance truck drivers who don’t burn much energy during their working day and often find themselves eating at fast food joints and greasy spoons.

However, the fact that something works for mice does not mean it will work for humans, so anyone who is hoping to ditch their running shorts and pop open a bottle of pills may have a long wait.

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Why Scientists Believe an Exercise Pill Might Be Possible

Exercise pillThe possibility of an exercise pill became big news when the scientific journal Cell Metabolism published the results of an eight-week study that showed the administration of an experimental drug had allowed laboratory mice to run on a treadmill for 270 minutes. This was a 70% longer than the mice that did not receive the drug and were exhausted after 160 minutes of treadmill activity.

Although the scientists were primarily more interested in the drug’s effect on endurance, they discovered it produced some other interesting changes. The mice that received it were also resistant to weight gain. They had better control of their blood sugar levels too, so the scientists believe the drug may also be capable of helping people who suffer from diabetes.

The team of scientists was based at the Salk Institute in San Diego and headed by Ronald Evans, who said they began by asking themselves a question: “If we really understand the science, can we replace training with a drug?”

Previous research had shown the drug GW501516 was capable of improving stamina and accelerating fat burning, so it was the obvious choice. A series of tests, involving mice running on treadmills, revealed administration of the drug changed the activity of more than 900 genes.

Many of the genes that showed increased activity were necessary for breaking down and burning stores of body fat. A number of genes that showed a decrease in activity were needed to convert sugar into energy, so the drug appears to program the body to attain more energy from fat and less from sugar.

woman exercising

The scientists believe the data they obtained may explain why runners and other athletes “hit the wall” when they push themselves too hard and find it hard to continue with their chosen exercise activity. People hit the wall when their blood sugar level drops, but GW501516 appears to have the ability to ensure blood sugar levels are maintained for longer periods of time.

According to the scientists, hitting the wall in endurance sports is a “dramatic demonstration of sudden and complete exhaustion.” The drug apparently works via special muscle proteins, called PPARD, in a way that is able to “dramatically improve endurance capacity.”

Weiwei Fan, the paper’s first author, states: “Exercise activates PPARD, but we’re showing you can do the same thing without mechanical training. It means you can improve endurance to the equivalent level as someone in training, but without the physical effort.”

GW501516 Creation and Controversy

GW501516 is not a new drug. It was developed in the 1990s by GlaxoSmithKline and Ligand Pharmaceuticals. It initially showed promise as a treatment for metabolic and cardiovascular diseases, but fell out of favor when several early studies showed high doses may cause cancer.

banned diet pillHowever, despite the risks its use presented, scientists continued to find the drug worthy of further study. Tests conducted at the turn of the century revealed its stamina boosting capabilities, it became a popular item on the black market, and some athletes taking part in the 2008 Beijing Olympics were banned when it showed up in their systems. GW501516 was banned by the World Anti-Doping Agency the following year because it was deemed to be unsafe.

University of Hertfordshire pharmacologist, Louise MacKenzie, has studied the drug in the past and feels it is not without potential when administered in low doses, but points out how dangerous higher doses can be. “It goes from being remarkably healthy to being the complete opposite. There’s no in-between,” MacKenzie explained.

Professor Ali Tavassoli (chemical biology department, Southampton University) also has doubts about the viability of an exercise pill. “There is a big difference between showing an organism can mimic exercise over the short-term and demonstrating the long-term effects of doing this,” Tavassoli said. “Someone with obesity or diabetes could be taking pills for 40 or 50 years. What happens when you take a drug like this for that long? These are big unanswered questions. I can’t see these things getting regulatory approval.”

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Best Fat Burners For 2017

Fat BurnerBest Fat Burner For 2017 – If you are reading this page because you’re trying to find a fat burner that works, you are already probably aware that around 99% of the fat burning diet pills on the market are a waste of time and money.

Many of them contain dangerous or ineffective ingredients. Even when the formulation does contain good ingredients some products fail to work because greedy manufactures have scrimped on the amount included and bulked up their pills with useless fillers.

The fact that some manufacturers trick people into signing up for auto-ship programs, that involve hefty recurring costs, only goes to make a bad situation worse. It’s no wonder so many dieters give up hope. There are good fat burners out there though. The only problem is, unless you have the knowledge and experience needed to see past the hype and the scams, it can be like searching for a needle in a haystack.

Our list of best fat burners for 2017 may not be long, but it contains three of most powerful diet pills money can buy. They don’t contain any dangerous ingredients and they don’t have a history of causing side effects, but they do have a reputation for delivering results and have already helped thousands of people to reach their ideal weight. Our top three fat burners also share another common trait—they are backed by a money back guarantee.

PhenQ – Fat Burner With Multi Benefit

PhenQ has already helped more than 190,000 people to lose weight, and it’s generally believed to be the best diet pill in the world, so it’s the most appropriate choice to top our list of best fat burners for 2017. Its only been on the market since 2015, but any fat burner that has helped so many people to get back into shape, in such a short space of time, must have a lot going for it.

PhenQ multi benefit diet pillOne of the things that gives PhenQ an edge over the competition is the fact that it contains a fantastic new ingredient called α-Lacys Reset. Scientific study shows α-Lacys Reset can boost fat burning abilities by 7.24% and increase muscle mass at the same time.

When muscle mass increases the extra muscle tissue increases calorie expenditure. This is one of the main reasons people who lose weight with PhenQ find the weight stays off. If yo-yo dieting has been a problem in the past, PhenQ is the answer.

Another reason PhenQ works so well is because it combines fat burning with other benefits that can help dieters make progress faster. Appetite suppression and fat blocking are just two of them. Check out our review to read the rest

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Phen375 – Dual Action Fat Burner

Here we go again, it’s another Phen-type supplement, but take a close look at the number. It’s “375” and it’s an excellent fat burner. So good, in fact, it has become a victim of its own success. Phen375 has helped so many dieters to burn fat and lose weight it’s got a lot of people talking and recommending it to their friends.

Phen375 recommendedThis has encouraged other diet pill manufacturers to produce products with similar-sounding names in the hopes of cashing in on Phen375’s success. This is a big problem because it is incredibly easy to go searching online and accidentally purchase Phen[another number] instead.

Phen375 is manufactured in an FDA approved facility in the USA and it’s only available from the manufacturer’s website. It’s designed to make fat burning faster and easier and it achieves this by utilizing a blend of the best pharmaceutical grade natural ingredients.

Like PhenQ, Phen375 is a lot more than just a fat burner. It’s also designed to take away hunger cravings and customer reviews show it does just that. The formulation also contains ingredients that offer dieters further support, so Phen375 is a good all-rounder. You can find out more by reading our review

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Capsiplex – Chili Fat Burner

The third entry on our list of best fat burners for 2017 is Capsiplex. It’s a powerful product that torches body fat by harnessing the ability of compounds taken from chili peppers. So it’s a hot property in more ways than one.

The capsaicinoids sourced from the fruit’s fiery core have the ability to boost the metabolism for up to 24-hours, causing the body to burn calories much faster. They also help suppress the appetite. These abilities alone are capable of supporting weight loss, but they pale to insignificance when compared to the compound’s abilities as a thermogenic fat burner.

Capsiplex chili diet pillThermogenic fat burners trigger a slight elevation in body temperature that causes the body to begin burning extra calories and losing them in the form of heat. The capsaicinoids in Capsiplex are highly concentrated and they have been blended with an ingredient that helps them to be absorbed faster than would normally be the case. It’s a very potent fat burning product that helps people to burn 12 times as much fat as normal—even during periods of low activity.

Capsiplex succeeded in catching the attention of the British Actress, Roxanne Pallett. She loved it so much she agreed to become the brand ambassador. Feedback from customers shows a lot of other people love Capsiplex too. To find out more read our review

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What Are The Best Diet Pills For 2017

Want to find the best diet pills for 2017? We can help. Every year we take a look at the various options available and select the three that are best equipped to deliver results. The products we’ve selected for our list of best diet pills for 2017 all share several things in common. They contains ingredients that are known to deliver safe weight loss, they have excellent customer feedback, and they come with a money back guarantee.

The Top Diet Pills for 2017

PhenQ multi benefit diet pillPhenQ – This diet pill can’t be beaten as far as we are concerned. It was launched in 2015 and quite literally took the world by storm. At the time of its release, most other diet pills came with a 30-day money back guarantee and some had none at all. So when people heard there was a new diet pill being sold with a 60-day money back guarantee they sat up and took notice.

The extra 30-days allowed customers plenty of time to evaluate PhenQ and they knew they had nothing to lose because a refund was available. People began buying the pills, discovered they worked well, and the positive feedback started to flood in. This encouraged more people to buy PhenQ and it became a best-selling diet pill.
Why PhenQ is Such a Safe Bet for Weight Loss

The secret to PhenQ’s success is very simple. It contains a blend of good weight loss ingredients that cover all the bases and give dieters the total support they need.

The PhenQ formulation assists weight loss in five ways:

  • Suppressing the appetite
  • Accelerating fat burning abilities
  • Acting as a fat blocker
  • Boosting energy levels
  • Enhancing the mood

PhenQ what does it doDiets fail for many reasons. Some people find eating less makes them feel tired and moody, others find it hard to say no to food. Whatever your failings are as a dieter, PhenQ has you covered and experts agree supplements that provide all around support offer the best results.

Other good things about PhenQ include:

  • No exaggerated claims
  • Reasonable price
  • No extra charges for P&P

Read Our Full PhenQ Review

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Superfruit Slim bottle
Superfruit Slim – We’ve been recommending Superfruit Slim for a number of years. It can be especially good for people who do not tolerate stimulants well and, last year, the manufacturer doubled the guarantee period they were offering. It’s now 60-days, just like PhenQ.

As the name suggests, Superfruit Slim is a diet pill that contains superfruits. This is a name that is given to a number of fruits that are known to be very nutritious and good for helping people to lose weight. The formulation harnesses the fat-fighting abilities of two of the most powerful superfruits in the world (acai and African mango) and backs them up with the proven thermogenic fat burning capabilties of green tea and the health boosting abilities of panax ginseng.

SuperFruit Slim 3 bottlesDieters using Superfruit Slim will find it easier to control their food cravings and start burning more fat. It’s one of the healthiest, most effective diet pills in the world.
Other Good Things About Superfruit Slim Include:

  • Contains powerful 4:1 extracts (four times the strength of the normal ingredient)
  • Suitable for vegetarians
  • Competitive pricing

Read Our Full Superfruit Slim Review

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Gravitate Nutrition Supersculpt and DietvitsGravitate SuperSculpt SuperSculpt is an appetite suppressant produced in Manchester by Gravitate Nutrition. It’s a little unusual because it’s designed to be used alongside a companion product, called DietVits, and combine weight loss with other health improvements. When we first heard about the products we were concerned the two-in-one approach was intended to encourage dieters to pay more. We were wrong about that. The combo is very reasonably priced and it’s possible to buy both supplements for less money than many standalone products cost. Gravitate Nutrition also offers customers a 35-day money back guarantee. That’s not as good as the guarantee offered to customers who buy PhenQ or Superfruit Slim, but it is long enough for dieters to see what the products can do.

When they are used together, the two Gravitate products are designed to deliver the following benefits:

  • Appetite suppression.
  • Boosted metabolism
  • Carb-blocking
  • Faster fat burning
  • Become healthier, happier, and more energised

Gravitate NutritionGravitate Supersculpt contains one of the best appetite suppressing ingredients in the world—glucomannan. So anyone who uses the product in the recommended way will find it easier to eat less food and begin burning fat for extra energy. Several of the vitamins and minerals in the DietVits formulation are also known to support weight loss and will be undoubtedly good for the health.

Other Good Things About Gravitate Supersculpt Include:

  • Option to buy a 14-day trial pack
  • Some customers report losing a stone in 30 days
  • Free weight loss guide specially developed to help Gravitate customers get the best results possible.

Read Our Full Gravitate SuperSculpt Review

New Atkins Diet Pill May Help You to Lose Weight Fast

Atkins Diet PillA little over a decade ago the Atkins Diet was all the rage. One in 11 North American adults claimed they were following an Atkins-type low-carb diet and over three million people in the UK were doing likewise. Now scientists believe it may be possible for people to reap the same Atkins Diet benefits without the need for extreme dieting techniques.

The Atkins Diet takes its name from Dr Robert Atkins, who believed it was possible to ramp-up the body’s fat burning abilities by eating a high protein diet that mostly consisted of meat, fish, and eggs. During the late 1990s, the low carb dieting technique he advocated became very popular with many Hollywood celebrities, including Renee Zellweger and Jennifer Aniston. Although it is deemed by some to be too extreme and is often considered dangerous, the diet remains popular to this day. When Kim Kardashian needed to lose weight after giving birth to her second child, in December 2015, she used the Atkins Diet in conjunction with diet and exercise and successfully shed 60 pounds.

Researchers at Imperial College London have discovered the high protein foods that are so important to the Atkins Diet trigger the release of the chemical phenylalanine. This suppresses the hunger hormone, ghrelin, and increases levels of the appetite suppressing hormone GLP-1.

Kevin Murphy, Professor of Endocrinology at Imperial College London, states all foods have the ability to stimulate the two hormones but pointed out protein has a greater effect on GLP-1 levels than other nutrients do. He also expressed fears that high protein diets may not be ideal for the health.

“I think people don’t stick to high protein diets,” Murphy said, “and there is evidence they might not be great for you in the longer term. So, if you exploit this in a pill, that would be great.”

The dangers the Atkins Diet can present are well known and some experts believe such a diet may increase the risk of heart disease. Research conducted at the University of Aberdeen suggests cutting down carbohydrate intake may also reduce levels of gut-living bacteria that lower the risk of cancer. Some data also reveals people who follow the Atkins Diet and other similar low-carb dieting methods may face an increased risk of kidney damage.

A diet pill that can deliver all the benefits of the Atkins Diet, without the need to consume high amounts of protein, sounds good, but there’s a problem. The study conducted at Imperial College London was carried out on rodents. Similar results cannot be guaranteed for humans.

The rodents involved in the study were given doses of phenylalanine for a week. This caused them to lose weight and the scientists believe this is was because it triggered hormonal changes that suppressed their appetites and allowed them to be content with fewer calories per day.

When the scientists examined the rodent’s gut cells in a Petri-dish they discovered the phenylalanine had interacted with a calcium-sensing receptor. They believe this reaction had triggered a signal that took away the desire for food.

Bearing in mind the possible dangers faced by Atkins dieters, and the fact that so many people swear the system works, an Atkins Diet pill could be a valuable asset in the war against obesity. Lead author Mariana Norton stated: “Our task is to demonstrate activating CaSR [calcium sensing receptor] can suppress the appetite. It highlights the potential use of phenylalanine or other molecules that stimulate CaSR—like food components or drugs—to treat or prevent obesity.”

It’s early days yet, and the fact that the scientists have yet to prove the pill would work for humans remains a problem, but the results of the study are being presented today at the annual Society for Endocrinology conference in Brighton.

What diet pills are the most popular in countries such as the UK, USA and Australia

 

Best Natural Ingredients Used In Diet Pills To Suppress Appetite

Here is a list of the best appetite suppressing ingredients – these are found in many of todays best diet pills available without prescription

Nopal

Nopal appetite suppressantAn ingredient that often goes by the name “prickly pear”. It’s a cactus extract that has a long history of use and an excellent reputation for delivering results. Some studies suggest supplementation with nopal may also help discourage fluid retention. Nopal is nothing if not versatile though.

Researchers have recently discovered the ingredient can further assist weight loss by acting as a fat blocker. Read which diet pill includes Nopal

Garcinia Cambogia

garcinia cambogiaAn ingredient that is extracted from a tropical fruit. The rind of the fruit contains is a source of hydroxycitric acid (HCA). If you have already read our article about the 10 Best Fat Burning Ingredients you will be aware HCA is a respected fat burner.

Mother Nature has been particularly generous with garcinia cambogia because the HCA it provides also has the ability to suppress the appetite by stimulating the release of extra serotonin. Read which diet pills are best that contains Garcinia Cambogia

Cayenne

capsimax powderGarcinia cambogia is not the only appetite suppressant that doubles as a fat burner. Cayenne has a similar ability. The appetite suppressing powers of cayenne were put to the test by researchers at Laval University in Canada.

The researchers enlisted the help of a group of female volunteers and monitored the way they reacted to a combination of cayenne and meals that were high in fat or carbohydrate. The researchers finally concluded: “These results indicate that the ingestion of red pepper decreases appetite and subsequent protein and fat intakes.” Capsimax powder is best the example of a commercially developed weight loss product

Glucomannan

glucomannan-Konjac rootGlucomannan is a water-soluble natural fiber that is derived from the roots of elephant yam (Amorphophallus konjac). It is capable of absorbing large quantities of water and the process happens quite fast, causing the fibers to expand. When glucomannan is consumed with an adequate amount of water, and this process occurs withing the stomach, the expanded fibers fill up the stomach cavity to create a feeling of fullness that lessens the desire for food.

The appetite suppressing abilities of glucomannan have been proven again and again, by researchers all over the world, and experts at the European Food Safety Authority (EFSA) have examined the data and agree the ingredient works. However, the EFSA states good results require dieters to take 1g of glucomannan three times each day, before meals. The EFSA also point out the importance of taking glucomannan with 1-2 glasses of water and using the ingredient with a low calorie diet. Read about a brand new product that contains Glucomannan

Caffeine

Many coffee lovers have probably noticed it can help take the edge off their appetite. Coffee is blessed with this ability because of it is such a good source of caffeine. The appetite suppressing abilities of caffeine can be scientifically supported by the results of a study conducted in Greece. Thirty-three volunteers took part. Some of them received coffee with their breakfast, others got water and the resultant data showed the caffeine in coffee had a suppressing effect on the appetite and helped the volunteers to reduce their “energy intake”.

Guarana

Guarana is a fruit extract that is high in caffeine. Although the appetite suppressing abilities of caffeine have already been explained, guarana deserves a special mention because it delivers its caffeine content slower than other caffeine-providing ingredients. This allows guarana to continue providing benefits for a longer period of time and makes it especially useful for helping to curb the desire to snack between meals.

Chromium

A mineral that can suppress cravings for sugary food. This is achieved by chromium’s ability to control blood sugar levels. Research conducted in America suggest chromium’s reputation in this regard is not without founding. After an eight-week study, involving 113 adults who were clinically depressed and prone to sugar cravings, the scientists concluded: “The results of this study suggest the main effect of chromium was on carbohydrate craving and appetite regulation in depressed patients and that chromium may be beneficial for patients with atypical depression who also have severe carbohydrate craving.”

Yerba Mate

Yerba mate is a member of the holly family and, in South American culture, it often brewed and drunk as a tea. It is also highly valued for its powers of stimulation. Yerba mate has been favoured as an appetite suppressant by Guarani Indian tribes for many hundreds of years and a number of clinical trials suggest yerba mate also has a lot to offer as fat burner.

Hoodia Gordonii

Hoodia gordonii is a natural ingredient sourced from a cactus-like succulent shrub. Hoodia has such a good reputation for suppressing the appetite many diet pill manufacturers use it as a standalone ingredient. Researchers at the Council for Scientific and Industrial Research in South Africa tried to identify the components that provide hoodia with its appetite suppressing abilities. They isolated two compounds. Subsequent tests, conducted on rats, showed both compounds have the ability to provide appetite suppression.

Caralluma Fimbriata

Caralluma fimbriata has been used as an appetite suppressant in India for many centuries and, like hoodia gordonii, it is sourced from a succulent plant. The appetite suppressing ability of caralluma fimbriata was examined by a research team in Bangalore, India. A mixed sex group of adult volunteers were given 1g of caralluma fimbriata or a placebo and the group who received the plant extract reported reduced hunger levels and lost more weight than the placebo group. The researchers concluded: “Caralluma extract appears to suppress appetite, and reduce waist circumference when compared to placebo over a 2 month period.”