Mysimba Review – Naltrexone (90mg) Bupropion (78mg) – Sold as Contrave

MySimba Diet Pill UKMysimba is a prescription weight loss medication developed in the US my Orexigen Therapeutics. It provides a combination of Buprion and Naltrexone and has been distributed in the US under the Contrave brand name since 2014. Mysimba was not approved for use in the UK until 2017.

Although it is good that doctors in the UK now have another weight loss drug at their disposal, potential Mysimba users need to be aware the medication is capable of causing side effects and does not compare well to some non-prescription alternatives that are safer to use and have a better reputation for delivering results.

A combination of scientific data (collected from clinical trials) and customer feedback suggests the medication is only effective for 50% to 60% of users.

PhenQ multi benefit diet pillThe commercial diet pill market has some highly effective products at it’s disposal that do not need a prescription.

PhenQ for example can be purchased directly from it’s own official website. There is a 60 day money back guarantee effective on all purchases and the products ships without a delivery cost anywhere in the world.

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What is Mysimba and How Does it Work? 

Mysimba is an appetite suppressant. Appetite suppressants help people to lose weight by controlling the hunger urges that are normally experienced when the switch is made to a low-calorie diet.

The appetite can be suppressed in a number of different ways. Some supplements achieve this by creating a feeling of satiety in the stomach. Mysimba does so by causing chemical changes that effect the brain and lessen the desire for food.

MySimba prescription only

Key Ingredients and Blend Potential

Each Mysimba tablet provides

  • Naltrexone (90mg)
  • Bupropion (78mg)

MySimba or ContraveBoth drugs are prescribed, individually, as treatments for certain medical conditions. Bupropion is commonly used as an antidepressant and smoking cessation aid. Naltrexone is an an anti-addiction medication.

Scientists noticed people who were using Bupropion as an antidepressant often lost weight.

They have speculated that this because the drug boosts dopamine levels in the brain and makes the body use more energy and burn extra calories.

Naltrexone appears to assist this process and can further support the weight loss process by making sweet foods seem less palatable.

Usage Instructions – The tablets should be taken with water and swallowed whole, preferably with food.

The treatment begins with a dose of one tablet per day and is gradually escalated, over a four-week period.

  • Week 1: One tablet in the morning
  • Week 2: One tablet in the morning and another in the evening
  • Week 3: Two tablets in the morning. One tablet in the evening.
  • Week 4 onwards: Two tablets every morning. Two tablets in the evening

Clinical Trials

Four clinical trial have been conducted on Mysimba. After 16 weeks, 50.8% of users attained weight loss of 5% or more. After a year the average weight loss was 10%.

MySimba Customer Feedback

We were unable to find any customer feedback for Mysimba, but has plenty of feedback for Contrave. It’s the same medication sold under a different brand name, so it provides a good insight into how the medication is likely to perform.

Contrave customer reviews suggest Mysimba may only be beneficial for around 60% of users.

A few average comments read:

“I didn’t start losing weight with contrave until I began with the full dose. Now I’m dropping around 6 pounds a week. I have not experienced any side effects and feel more energized and focused.” 

“This weight loss drug appeared to work for me, but I had to stop because of all the terrible side effects. It gave me a bad head, made me sweat like a pig, and made me so irritable I could not stand having my family around me.”

“I began using Contrave on April 10th, 2016, and 4 months later I had lost 62 pounds. I was exercising as well and eating right too, but I was doing these things before and never lost any weight until my doctor prescribed Contrave.”

“Dieting is easier now because I am no longer pestered by hunger pangs. I’ve lost 6lbs, but the side effects mean I am going to have to stop. I feel sick a lot, get banging headaches, and have fallen victim to constipation.”

MySimba Side Effects

Mysimba can cause unfavourable reactions when it is used alongside some other medications. It is also unsuitable for people who are suffering from certain medical conditions, such as uncontrolled hypertension.

The most commonly reported side effects are headaches, nausea abdominal pain, restlessness, joint pain, and dizziness. A few rarer side effects include suicidal thoughts, liver damage, and manic episodes. In clinical studies, 23.8% of the participants reported adverse effects and discontinued using it.

Purchasing Options & Considerations

Mysimba is a prescription-only medication. You will only be able to obtain it if your GP prescribes it and many people who are overweight may not be eligible for a prescription.

Doctors in the UK are only allowed to prescribe weight management drugs to people who are so obese they have a BMI of 30 or more. To be eligible for a Mysimba prescription, patients will also need to suffer from a medical condition that may be made worse by the fact that they have become so overweight.

The Bottom Line

Mysimba appears to have value as a weight loss aid, but customer reviews and scientific data suggest it does not work for all and the potential for side effects may be quite high.

Suppressing the appetite is only one of several ways to lose weight. Many of the best diet supplements are designed to provide appetite suppression, enhance the body’s natural fat burning abilities, and provide additional support to dieters in other ways.

This is achieved without the risk of side effects and such supplements generally come with a money back guarantee. Customers who present a Mysimba prescription to their local pharmacist are not offered such a financial safety net.

If the medication fails to work for them, or they have to stop taking it due to side effects, their money is gone. Bearing this in mind, that old adage “doctor knows best” does not appear to be a universal truth.

Which are the best diet pills to buy that do not need a prescription – click here

Xenical Fat Blocker – available by prescription only

Xenical fat blockerXenical (Orlistat) is a powerful fat blocking drug that can only be obtained by people whose weight-related health issues or overall obesity has become so bad they have been provided with a doctor’s prescription.

The drug is so renowned for getting results many people would love to be able to incorporate Xenical into their weight management programs, but obtaining a prescription is not easy.

Doctors are rarely willing to prescribe Xenical to anyone who has a Body Mass Index (BMI) less than 30. So unless the patient’s weight is likely to have a dangerous impact on existing medical conditions, such as a weak heart, or the BMI meets the required limit, the changes of getting a prescription are pretty slim.

PhenQ appetite suppressantXenical main caveats are is propensity to cause side effects and its lack of availability due to its prescription only status.

For this reason an opportunity was opened for the excellent PhenQ. PhenQ works in much the same way as Xenical – it advantages are its natural, so does not cause side effects and it is available to buy direct without prescription.

Read more on PhenQ

How Xenical Works

Xenical is a fat blocker, it is the brand that the Orlistat is marketed under. Fat is a high calorie nutrient and many overweight people have too much fat in their diets.

Fat blockers interfere with the digestive system’s ability to process fat, causing most of any dietary fat that is ingested to simply pass through the body without releasing any of the calories stored inside it.

The use of fat blockers can be an extremely effective means of lowering the amount of calories that are obtained each day, but the fact that so much fat is passing through the body in an undigested state invariably leads to greasy stools.

In the case of people who continue to eat high fat diets it can also lead to nasty surprises because the undigested fat can reach its ultimate destination quite quickly. However, when used in conjunction with a healthy diet, fat blockers like Xenical can be very effective weight loss providers.

How Xenical works

The Need for Restrictions

Xenical is not a diet supplement. It’s a drug, and like any drug its use may result in side effects; so it is important that a doctor is monitoring the situation and can adjust the dosage or stop the treatment if the need should arise.

It is not unheard of for Xenical users to experience painful skin rashes, but the majority of possible negative issues are likely to be restricted to certain user groups. Xenical is not suitable for everyone. It can react badly with some medications, and may be transferred to the breast milk of nursing mothers.

Other user groups that may find Xenical an unsuitable option include:

  • Diabetics
  • People who have liver or kidney problems
  • People who have thyroid problems
  • People who suffer from anorexia, bulimia, or other eating disorders

Fortunately, the prescribing doctor will be aware of the patient’s medical status and will be able to make an informed decision about the suitability of the drug.

Dosage – The usual dosage is 120mg, but this may be changed at the prescribing doctor’s discretion, and the capsules should be used a part of an overall weight management regimen that includes a healthy diet plan that provides no more than 30% fat. Xenical users usually eat three meals per day and take the capsules with water just before dining, but if a meal is missed, or does not contain any fat to block, the medication will not be required because there will be no fat in the stomach for it to work upon.

Health permitting (again the prescribing doctor will usually advise) Xenical usage may be combined with physical exercise to encourage improved weight loss results.

The Bottom Line

There can be no doubt about the value of Xenical as a treatment for obesity, but the fact that someone has developed bingo wings or unsightly love handles is not likely to make them a likely candidate for a prescription. Like any drug, Xenical demands respect and its present prescription-only status is unlikely to change.

When used under a doctor’s supervision, it has the power to change lives for the better and, bearing in mind the health dangers faced by those who are deemed viable users, perhaps to save lives as well.

Sufferers of obesity face greater risks of succumbing to heart attacks, strokes, or diabetes. They are more like to fall victim to osteoarthritis, sleep apnea, and numerous other conditions. Xenical may not be the only anti-obesity option available, but it remains one of the best and the fact that doctors consider to be a viable treatment is possibly the best endorsement of its abilities.

Similar Diet Pills Available Without Prescription

PhenQ multi benefit diet pillAs highlighted above PhenQ has been positioned as a non prescription alternative to Xenical. PhenQ is the latest formulation and includes completely natural ingredients.

PhenQ has been preferred by many as it does not present side effects as so often is the case with Xenical. PhenQ is also available to buy over the counter (direct from official distributor) without prescription.

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Contrave – prescription diet pill with Bupropion HCI and Naltrexone HCI

Contrave prescription diet pillContrave is a weight loss tablet manufactured in the US by Orexigen. Unlike most of the products evaluated on this site, Contrave is not a supplement.

It is a medication and it is only available to dieters who have obtained the necessary prescription, so in many ways it could be compared to Phentermine.

Like Phentermine, Contrave is only deemed suitable for patients who are seriously obese and are suffering from medical conditions that are related to, or aggravated by their extra poundage.

Claims: May help some obese patients who have weight related medical problems

Positives: FDA approved

Negatives: New to the market and does not come without risks. Not available to all and only by prescription

How the Formulation Works

Again, it is hard not to make comparisons between Contrave and Phentermine because both are designed to provide appetite suppression and neither one provides any other weight loss benefits such as fat burning or carb blocking.

hunger cravings on the 5:2 dietWhen it comes to losing weight it’s all a matter of calories. Get to many and you gain weight. Receive too few and the body is forced to begin burning body fat, but cutting down on calories by cutting down of food is not much fun. The hunger pangs can be unbearable, but a good appetite suppressant can take all of that away and help dieters attain their desired goals.

Unlike some other weight loss options, Contrave has been clinically tested and is proven to be effective. It use as a prescription medication has also been sanctioned by the Food and Drug Administration (FDA), but the FDA has not approved Contrave for use as a sole weight loss provider. The tablets must be used as part of weight management routine that includes healthy eating and increased levels of exercise.

Key Ingredients

A few binders and fillers are necessary to hold the tablets together, but the main ingredients are Bupropion Hydrochloride and Naltrexone Hydrochloride.

  • Bupropion Hydrochloride: A drug that stimulates areas of the brain. It is usually used to treat depression, but tests carried out at in the US (Duke University Medical Centre, Durham) show Bupropion Hydrochloride can also assist weight loss. Human test subjects achieved an average weight loss of 12.9%. [source]
  • Naltrexone Hydrochloride: A drug that is primarily used to help people who are battling alcohol or opioid addictions, Naltrexone Hydrochloride is not generally associated with weight loss. [source]

Supporting Information

The weight loss providing abilities of Contrave have been proven by two clinical trials. The volunteers who took part in both these trials consisted of overweight individuals and all of them suffered from one or more health problems. This is good because the physical condition of the test subjects was a match for the kind of users who will be prescribed the tablets. In both trials the group that received Contrave lost considerably more weight than the placebo group.

  • Study no. 1 — Contrave group 5.4% weight loss v 1.3% (placebo group).
  • Study no. 2 — Contrave group 8.1% weight loss v 4.9% (placebo group).

Usage Instructions

Patients are required to start with a dosage of 1 tablet a day and then work their way up to 4 tablets a day.

  • Week 1 — 1 tablet each morning.
  • Week 2 — 1 table each morning    + 1 tablet each evening.
  • Week 3 — 2 tablets each morning + 1 tablet each evening.
  • Week 4 — 2 tablets each morning + 2 tablets each evening.

The prescribing doctor will advise, but tablets must be used in conjunction with exercise and a healthy diet, and Orixigen warn against eating high fat meals because this increases the possibility of seizures.

Potential Contrave Side Effects

Bupropion hydrochloride can trigger a negative state of mind and, to Orexigen’s credit; their website displays a warning about this that is so in your face it would be very hard to miss:

“CONTRAVE can cause serious side effects of suicidal thoughts or actions.”

The site also provides a lengthy list of other possible side effects, including:

  • Rashes
  • Swollen glands
  • Eye problems
  • Stomach and/or intestinal problems
  • Headaches
  • Nausea
  • Difficulty sleeping
  • Seizures
  • Raised blood pressure
  • Chest pains
  • Changes to the heart rate
  • Liver damage
  • Hepatitis
  • Manic episodes

Contrave Testimonials & Feedback

Customer feedback indicates Contrave may work better for some users than others.

“I’ve been using Contrave for nearly 8 weeks, but I can’t see much difference so it’s a waste of time as far as I’m concerned. I’ll give it another 8 weeks and see what happens, but I’m feeling very disheartened at the moment. “

“3 weeks of dizziness and nausea. I don’t think I’ll be able to continue taking these for too much longer, they make me feel too ill.”

“I’m on day 12 and can already notice a big difference in my eating habits. Chocolate has lost its appeal. Cakes have lost their appeal. Hallelujah, finally an appetite suppressant that works. “

“I’ve been doing this for 3 weeks now and am as happy as Larry. I’ve lost 15lbs. That’s 5lbs for each week and I’ve not experienced any side effects at all.”

Availability – Can I Buy Contrave

Contrave cannot be legally obtained without a doctor’s prescription.

Non Prescription Alternative

Buy PhenQContrave has been likened to Phentermine, another prescription only diet pill – one product that has been incredibly popular over the last few years is PhenQ.

PhenQ is billed as a Phentermine alternative – it has a similar methodology (appetite suppressant) and can also act as a fat burner. PhenQ is available to buy direct from its own official website and does not require a prescription.

Read about PhenQ here